Nutritional Pathology: Pathobiochemistry of Dietary Imbalances

Portada
CRC Press, 1985 M04 25 - 416 páginas
It has become increasingly apparent that manipulations in nutrition -- exogenous or endogenous -- may be involved in the pathogenesis of many disease states ranging from metabolic disorders, such as diabetes and obesity, to the prime killer diseases, such as cancer and cardiovascular disease. This timely, authoritative reference examines several recent, major developments in the field of nutritional pathology, providing enhanced, current understanding of the role that altered or disturbed nutrition plays in the pathogenesis of disease. Approaching the effects of nutrition from a molecular biology perspective, Nutritional Pathology investigates specific pathological aspects of diet and dietary imbalances, including effects of malnutrition on pancreatic disease, cardiovascular disease, and the central nervous system ... the role of nutrition in drug metabolism and toxicity ... deficiencies in choline, tryptophan, and dietary fibers ... consequences of drug-induced malnutrition ... and much more. Well illustrated and extensively referenced for easy access to the broad expansion of research in this area, Nutritional Pathology will serve as an important resource for all researchers involved in this advancing science, including pathologists, nutritionists, biochemists, cell biologists, toxicologists, epidemiologists, pharmacologists, and oncologists. Moreover, this volume is an essential information source for graduate students in pathology, nutrition, and biochemistry. Book jacket.
 

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Contenido

Effect on the Liver
9
Effect on the Livers of Rats Treated with Hepatotoxic
27
Tryptophan and Pregnancy
34
Potential Importance of Tryptophan and Its Unique
40
TRANSLATIONAL CONTROLS OF PROTEIN SYNTHESIS
63
NUTRITIONALLY INDUCED PANCREATIC DISEASE
115
NUTRITION AND CARDIOVASCULAR DISEASE
127
88889
152
PATHOLOGY OF CHOLINE DEFICIENCY
279
Biochemistry of Choline
280
Pathological Lesions Induced by Choline Deficiency
283
Pathogenetic Mechanisms
286
Conclusions
303
References
305
ROLE OF NUTRITIONAL STATUS IN DRUG METABOLISM AND TOXICITY
321
Measurement of DrugMetabolizing Activity
323

5
161
Malnutrition and Synaptic Development
180
Amino Acids and Neurotransmitters
189
CatchUp Growth
190
Conclusions
194
References
196
ASPECTS OF NUTRITION PHARMACOLOGY AND PATHOLOGY
207
Dietary Fibers and Their Components
208
Physiological and Pharmacological Responses
217
Therapeutic Applications
233
Undesirable Effects and Pathological Responses
241
Fiber Bile Acids and Colon Cancer
246
Conclusions
253
Glossary of Terms
254
References
255
Consequences of Dietary Manipulation
324
Protein
325
Undernutrition
332
Carbohydrate
336
Lipids
338
Vitamins
341
Minerals
343
Phase2 Metabolism
344
Conclusion
346
References
347
PATHOLOGICAL CHANGES ASSOCIATED WITH
357
Spindle Poisons
364
Nutrient Depletion Secondary to DrugInduced
372
Index
381
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