Pain: Current Understanding, Emerging Therapies, and Novel Approaches to Drug DiscoveryChas Bountra, Rajesh Munglani, William K. Schmidt CRC Press, 2003 M05 13 - 968 páginas This reference presents a detailed overview of approaches and techniques in the management of pain caused by tissue, nerve and central nervous system injuries, categorizing pain into a variety of syndromes and underlying mechanisms to aid the development of interventional pharmacologic measures. |
Contenido
| 1 | |
| 9 | |
Chapter 3 From Acute to Chronic Pain Peripheral and Central Mechanisms | 29 |
Chapter 4 Central and Peripheral Components of Neuropathic Pain | 45 |
Chapter 5 A New Perspective on Signal Transduction in Neuropathic Pain | 71 |
Chapter 6 Pain and the Somatosensory Cortex | 87 |
Chapter 7 Descending Pathways in Spinal Cord Stimulation and Pain Control | 101 |
Chapter 8 Local Neuroimmune Interactions in Visceral Hyperalgesia | 119 |
Chapter 38 Profile of NSAID + Opioid Combination Analgesics | 491 |
Chapter 39 NSAIDs and COX2 Inhibitors | 499 |
Chapter 40 COX2Specific Inhibitors | 515 |
Chapter 41 NK Receptor Antagonists | 523 |
Chapter 42 Vanilloids | 531 |
Chapter 43 The Development of Bradykinin Antagonistsas Therapeutic Agents | 539 |
Chapter 44 The Treatment of Neuropathic Pain | 549 |
Chapter 45 NMethylDAspartate NMDA Receptors as a Target for Pain Therapy | 559 |
Chapter 9 Pain Processing in the Periphery | 135 |
Chapter 10 Neuroimaging of Pain | 149 |
Chapter 11 Surrogate Models of Pain | 161 |
Chapter 12 Acute Trauma and Postoperative Pain | 171 |
Chapter 13 Effectiveness of Needling Techniques with Special Reference to Myofascial Pain Syndromes | 179 |
Chapter 14 Advances in the Management of Spinal Pain and Radiofrequency Techniques | 189 |
Chapter 15 Pulsed Radiofrequency Treatment of Chronic Neck Back Sympathetic and Peripheral NeuromaDerived Pain | 213 |
Chapter 16 Spinal Cord Stimulation | 223 |
Chapter 17 Spinal Endoscopy | 239 |
Chapter 18 Cancer Pain Treatment | 251 |
Chapter 19 Inflammatory Joint Disease and Pain | 261 |
Chapter 20 Chronic Nonmalignant Visceral Pain Syndromes of the Abdomen Pelvis and Bladder and Chronic Urogenital and Rectal Pain | 269 |
Chapter 21 Nerve Injury Pain | 293 |
Chapter 22 Sympathetically Maintained Pain | 309 |
Chapter 23 Headache | 321 |
Chapter 24 Psychological Factors in Measurement of Pain | 331 |
Chapter 25 Challenges and Pitfalls of Clinical Trials | 337 |
Chapter 26 Molecular Approaches to the Study of Pain | 347 |
Chapter 27 Molecular Validation of Pain Targets | 355 |
Chapter 28 Genetics of Pain | 365 |
Chapter 29 Animal Models of Pain | 377 |
Chapter 30 An Overview of Current and Investigational Drugs for the Treatmentof Acute and Chronic Pain | 385 |
Chapter 31 Novel Mu Delta and Kappa Agonists | 407 |
Chapter 32 DeltaReceptor Nonpeptide Agonists | 421 |
Chapter 33 Peripheral Opioid Analgesia | 427 |
Chapter 34 Profile of ADL 21294 an Opioid Antihyperalgesic Agent with Selectivity for Peripheral MuOpiate Receptors | 435 |
Chapter 35 ControlledRelease Opioids | 449 |
Chapter 36 NMDAReceptor Antagonists as Enhancers of Analgesic Activity | 475 |
Chapter 37 CCK Antagonist Potentiation of Opioid Analgesia | 485 |
Chapter Profile of Ketamine CPP Dextromethorphan and Memantine | 575 |
Chapter 47 GV 196771 A a New Glycine Site Antagonist of the NMDA Receptor with Potent Antihyperalgesic Activity | 585 |
Chapter 48 VoltageGated Sodium Channels and Pain | 607 |
Chapter 49 Calcium Channel Antagonists and the Control of Pain | 619 |
Chapter 50 Profile of Ziconotide SNX111 | 629 |
Chapter 51 Nitric Oxide Synthase Inhibitors and the Role of Nitric Oxide in Nociception | 637 |
Chapter 52 Adenosine and Pain | 649 |
Chapter 53 Adenosine Kinase Inhibition as a Therapeutic Approach to Analgesia | 659 |
Chapter 54 P2X Purinergic Receptors for ATP in Nociception | 671 |
Chapter 55 Somatostatin Receptors in Analgesia | 677 |
Chapter 56 Cannabinoids | 683 |
Chapter 57 Antinociceptive Effects of Centrally Administered Neurotrophic Factors | 707 |
Chapter 58 Peripheral Neurotrophic Factors and Pain | 721 |
Chapter 59 Profile of Tramadol and Tramadol Analogues | 731 |
Chapter 60 Sumatriptan and Related 5HT1B 1D Receptor Agonists | 743 |
Chapter 61 Cholinergic Approaches to Pain Therapy | 749 |
Chapter 62 Analgesic Effects of Vedaclidine a Mixed AgonistAntagonist at Muscarinic Receptor Subtypes | 763 |
Chapter 63 Gabapentin and Related Compounds | 775 |
Chapter 64 The Role of Gabapentin in the Management of Neuropathic Pain | 781 |
Chapter 65 New Local Anesthetic Analgesics | 795 |
Chapter 66 Spinal Adrenergic Agonists for Intractable Cancer Pain | 803 |
Chapter 67 Cellular Implantation for the Treatmentof Chronic Pain | 815 |
Chapter 68 BoneSeeking Radiopharmaceuticalsto Palliate Painful Bone Metastases | 835 |
Currently Marketed AnalgesicsUSA 19982001 | 857 |
21Year Survey of Analgesicsin Development for Treatment of Acuteor Chronic Pain | 863 |
Further Readings | 935 |
| 949 | |
Back Cover | 976 |
Otras ediciones - Ver todas
Pain: Current Understanding, Emerging Therapies, and Novel Approaches to ... Chas Bountra,Rajesh Munglani,William K. Schmidt Sin vista previa disponible - 2003 |
Pain: Current Understanding, Emerging Therapies, and Novel Approaches to ... Chas Bountra,Rajesh Munglani,William K. Schmidt Sin vista previa disponible - 2019 |
Términos y frases comunes
action activity acute adenosine administration agents agonists allodynia analgesia analgesic analgesic effects anesthetic antinociception antinociceptive effects back pain BDNF behavioral block bradykinin Brain Res calcium channels cancer pain cannabinoid capsaicin cells central chronic pain Clin clinical clonidine compounds cytokines dorsal horn dorsal root dorsal root ganglion dose drug efficacy endogenous epidural fibers formalin gabapentin gene glutamate human hyperalgesia increased induced inflammation inflammatory inhibition inhibitors injection intrathecal ketamine kinase ligands mechanisms mediated mg/kg mice migraine modulation morphine mRNA nerve injury neuralgia neuropathic pain Neurosci NMDA receptor nociceptive nociceptors noxious NSAIDs opioid receptors oxycodone pain relief pain syndromes patients peptide Pharmacol Exp Ther pharmacological phase placebo postherpetic neuralgia potential primary afferent produced protein receptor antagonist release response role selective sensitization sensory neurons side effects spinal cord stimulation studies sympathetic therapeutic therapy thermal hyperalgesia tion tissue tramadol treatment trials trigeminal vedaclidine visceral ziconotide