Advances in Breast Cancer Management, 2nd edition

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William J. Gradishar, William C. Wood
Springer Science & Business Media, 2000 M08 31 - 211 páginas
The optimal management of breast cancer patients relies on the expertise of a team of medical specialists including radiologists, surgeons, radiation therapists and medical oncologists. Much of the progress in breast cancer management made over the last several years reflects the translation of observations made in the laboratory to the clinic. Critically evaluating the impact of new treatment approaches relies on a commitment to well-designed clinical trials. In this volume, Advances in Breast Cancer Management, a renowned group of breast cancer experts have been asked to provide their perspective on management issues that directly effect patients on a day-to-day basis. Dr. Melody Cobleigh discusses the consequences of estrogen deprivation and the ways of ameliorating secondary symptoms and the potential long-term morbidity. Drs. Haigh and Guiliano review the sentinel lymph node biopsy technique including results from their extensive experience. Dr. Abram Recht places into perspective the potential benefit of post-mastectomy radiotherapy and reviews recent trials that address this issue. Dr. Dennis Slamon takes from us from the laboratory to the clinic in explaining the development of Herceptin as a paradigm for therapy targeted to specific molecular characteristics of breast cancer tumor cells. Drs. Nieto, Shpall, Crump and Pritchard offer different perspectives on the future of high-dose chemotherapy with stem cell transplantation as a treatment for breast cancer patients. Drs.
 

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Contenido

Managing Menopausal Problems
1
Sentinel Lymphadenectomy In Node Negative Breast Cancer
25
Postmastectomy Radiotherapy
39
The Molecular and Cellular Biology of HER2neu Gene AmplificationOverexpression and the Clinical Development of Herceptin Trastuzumab Thera...
57
Highdose Chemotherapy for Breast Cancer
77
High Dose Therapy with Stem Cell Support for Breast Cancer The Jury Is Still Out
115
Preoperative Chemotherapy for Operable Breast Cancer
137
Overview of Randomized Trials of Systemic Adjuvant Therapy
157
Chemoprevention of Breast Cancer
183
Index
209
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