Aging and Human Longevity

Portada
Springer Science & Business Media, 1996 M12 1 - 284 páginas
The proportion of elderly people continues to increase in the western world-nearly a quarter of the population will be over 65 years by the year 2050. Since aging is accompanied by an increase in diseases and by a deterioration in well-being, finding solutions to these social, medical and psychological problems is necessarily a major goal for society. Scientists and medical practitioners are therefore faced with the urgent task of increasing basic knowledge of the biological processes that cause aging. More resources must be put into this research in order to achieve better understanding of the cellular mechanisms that underlie the differences in life span between species and to answer the difficult questions of why some individuals age more quickly than others, and why some develop liver problems, some have heart problems, and others brain problems. The results of such a wide program of research will provide important information about the causes of many life-threatening and/ or debilitating diseases of old age; it will help find ways to prevent some of the ailments that result from aging, and it may well lead to discoveries enabling the prolongation of human life.
 

Contenido

Variability of Life Span Between Species
7
Life Span of Humans
10
Life Spans of Invertebrates Honeybees
13
Life Span of Cells in Culture
17
Are Some Plants or Animal Species Immortal?
23
Factors That Influence Human Longevity
25
Influence of Personality Social Class and Social Interactions
27
The Role of Happiness and Marriage
29
Life Extension
131
Food Restriction in Nonhuman Species
132
Life Extension in Humans
136
Human Studies on Food Restriction
140
The Role of Diet in Longevity
142
Recommendations
143
Perspectives
145
Perspectives
151

Sexuality
30
The Role of Stress
32
Diseases of Premature Aging
40
A Note on Diseases and Longevity
44
Structural and Physiological Changes Occurring with Age
51
Connective Tissue
54
The Nervous System
55
The Endocrine System
60
Biological Clocks and Circadian Rhythmicity
62
Immune System
66
Aging of Intracellular Functions
70
Homeostasis and Multisystem Regulation
72
Theories of Aging
77
Programmed Theories
80
Overview of Aging Theories
82
Mechanisms of Cellular Aging
85
Intrinsic Mechanisms
86
Human Genetic Diseases Due to Somatic Mutations
95
DNA Methylation
110
DNA and Protein Glycation
111
Garbage Molecules
112
Free Radicals
113
Effects of Radiation
119
Apoptosis Diseases and Senescence
121
Conclusion of Part One
124
Introduction
129
Unsaturated Fats Omega3 and Omega6 Fatty Acids
155
Antioxidants and the Chemoprevention of Cancers and Cardiovascular Diseases
158
Aspirin
166
Life Styles
168
Sexuality
171
Physical Exercise
172
Smoking
177
Alcohol Consumption
183
Controlling Stress
187
Substitution of Endogenous Compounds and Hormones
190
Thymus Hormones
193
Dihydroepiandrosterone
196
Human Growth Hormone
198
Medications and Alternative Medicine
201
Alternative Medicine
204
Surgical Strategies
207
Perspectives in the Detection and Treatment of Diseases
210
Contribution of Genetic Engineering Techniques to Medicine
214
Application of Gene Therapy to Neurological Diseases
218
New Targets for Drug Therapy
225
Conclusion
228
Glossary
233
Relevant Books on Aging
241
References
247
Subject Index
277
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