Non-steroidal Anti-inflammatory Drugs

15 mg/kg bw aberrant crypt adenomas administration analgesic antimutagen apoptosis arachidonic acid aspirin associated azoxymethane Biochem bw per day Cancer Res cancer-preventive activity carcinogen carcinogen treatment carcinogenesis carcinoma case-control study cell lines clin clinical cohort colon cancer colon tumours colorectal cancer concentrations controls cyclooxygenase decreased disease DMBA evaluation excretion Experimental animals exposure familial adenomatous polyposis female fetal Fischer 344 rats Garcia Rodriguez gastric gastrointestinal gene genetic gestation given hamster human incidence increased indo indomethacin induced inhibition inhibitors intestinal ISBN 92 kinetics lesions liver male mammary metabolism metabolites methacin mice models mucosa multiplicity mutagen natl nonsteroidal anti-inflammatory drugs NSAIDs observed oral patients pharmacokinetics Pharmacol piroxicam placebo plasma pregnancy prevention proliferation prostaglandin protein randomized rectal Reddy reduced renal reported reverse mutation rheumatoid arthritis risk for colorectal salicylic acid significant Sprague-Dawley subcutaneous sulindac tion toxicity treated trials tumours typhimurium ulcer urinary vitro vivo weeks