Psychiatric Genetics and Genomics
Revised for paperback edition, with new appendices Genetics promises to provide one of the most powerful approaches to understanding the functional pathology of the human brain. This book presents a critical review of the evidence for a genetic contribution to common psychiatric conditions and the rarer single-gene disorders that may have psychiatric presentations. The first section of the book introduces the reader to molecular biology and the techniques of molecular genetics. The coverage then moves on to consider the genetics of normal and abnormal development, followed by a look at the genetics of abnormal behaviour in adults. This section includes, amongst others, consideration of personality disorders, schizophrenia and the dementias. The final section considers the applications of the work and covers issues such as counselling and ethics, closing with a look to the future. The editors are internationally renowned figures in this field and they have invited a team of equally eminent chapter authors.
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Basic molecular genetics
Linkage and association
The genetics of normal and abnormal development
Personality and cognitive abilities
Genetics of mental retardation
Reading and language disorders
Anxiety and eating disorders
Applications and implications
Ethical considerations in psychiatric genetics
The future and postgenomic psychiatry
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abnormalities abuse ADHD adolescents adoption studies affective disorder Agoraphobia allele Alzheimer's disease antisocial behaviour anxiety disorders APOE Apolipoprotein Archives association studies autism bipolar disorder candidate genes cent chromosome clinical clozapine cognitive abilities comorbidity concordance correlation dementia diagnosis dopamine drug DSM-III environment evidence family studies female genetic and environmental genetic influence genetic research genetic studies genome genotype heritability Hum Genet human Huntington's disease identified increased individuals inheritance interaction Journal of Psychiatry Kendler K. S. loci locus lod score major depression male markers McGuffin mental retardation mice molecular genetic mutations non-shared onset parents personality disorder phenotype phobia Plomin polymorphism population prevalence probands protein psychiatric disorders psychiatric genetics Psychiatry quantitative rates receptor gene region replication reported risk factors sample schizophrenia sequence serotonin transporter siblings specific suggest susceptibility symptoms syndrome traits transmission twin pairs twin study unipolar variance variation