Hormones, Genes, and CancerOxford University Press, 2003 M03 13 - 484 páginas Hormonal carcinogenesis is an important and controversial area of current research. In addition to accelerating existing cancers, can hormones play the role of primary carcinogens? How do genetic factors influence hormone-related cancer risk? Hormones, Genes, and Cancer addresses these questions. Over the past few decades, cancer research has focused on external environmental causes(e.g., tobacco smoke, viruses, asbestos). With the advent of new genetic sequencing techniques, we are just now beginning to understand how the body's internal environment(i.e., the hormones and growth factors that determine normal development) influences cancer etiology and prevention. From molecular insights to clinical analyses, this volume provides state-of-the-art information on the complex interactions between hormones and genes and cancer. The epidemiology and molecular endocrinology of prostate, breast, uterine, ovarian and testicular cancer are detailed in this timely treatise. |
Contenido
| 1 | |
2 Biosynthesis Transport and Metabolism of Steroid Hormones | 12 |
3 The Nuclear Receptor Superfamily | 38 |
4 Genomic Approaches to the Genetics of HormoneResponsive Cancer | 99 |
Epidemiology and Molecular Endocrinology | 120 |
6 The Impact of Exogenous Hormone Use on Breast Cancer Risk | 139 |
7 An Overview of Genetic Predisposition and the Search for Predisposing Genes for Breast Cancer | 157 |
P450 Aromatase | 169 |
13 Other Hormonal Prevention Strategies | 248 |
14 Progression from HormoneDependent to HormoneIndependent Breast Cancer | 255 |
Epidemiology and Molecular Endocrinology | 273 |
16 Androgen Receptor Signaling in Prostate Cancer | 288 |
The Search for Major Genes and the Role of Genes Involved in Androgen Action | 316 |
Mechanistic Insights | 331 |
19 Hormonal Therapies for Prostate Cancer | 343 |
Epidemiology and Molecular Endocrinology | 371 |
HSD17B1 and HSD17B2 | 181 |
Intervention in BRCA1 and BRCA2 Families | 199 |
11 Implications of Hormones and Hormonal Risk Factors on Screening Strategies | 210 |
12 Hormonal Chemoprevention with Tamoxifen and Selective Estrogen Receptor Modulators | 218 |
Epidemiology and Molecular Endocrinology | 398 |
Epidemiology and Molecular Endocrinology | 413 |
| 437 | |
Otras ediciones - Ver todas
Hormones, Genes, and Cancer Brian E. Henderson,Bruce Ponder,Ronald K. Ross Vista previa limitada - 2003 |
Hormones, Genes, and Cancer Brian E. Henderson,Bruce A. J. Ponder,Ronald Keith Ross Sin vista previa disponible - 2003 |
Términos y frases comunes
Acad Sci USA adrenal agonist allele analysis androgen receptor antiestrogens aromatase associated binding Biol Chem BRCA1 BRCA2 breast cancer breast cancer risk Cancer Res carcinoma ceptor chromosome clinical coactivator corepressor cytochrome disease domain effect encoding endometrial cancer enzyme Epidemiol estradiol estrogen receptor estrone exon expression function genome growth factor Her2/Neu hormone therapy interaction levels ligand linkage mammographic menopausal metabolism Mol Cell Mol Endocrinol molecular mRNA mutations Natl Acad Sci Natl Cancer Inst nuclear receptor Oncol oral contraceptives ovarian cancer ovary pathway patients Pike MC polymorphism postmenopausal women premenopausal Proc Natl Acad progesterone prostate cancer prostate cancer risk protein raloxifene reduced region regulation response element retinoic acid risk factors risk of breast role Ross RK sequence serum specific Steroid Biochem steroid hormones tamoxifen target testicular cancer testosterone tion tissue transactivation transcriptional activity trial trogen tumors Urol variants