Tamoxifen: Beyond the Antiestrogen

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Springer Science & Business Media, 1996 M04 1 - 378 páginas
Tamoxifen has persisted as a widely accepted and administered drug for almost 25 years. Following the many scientific papers and books on the subject, it has remained a very intriguing substance. This, perhaps, is the reason for another monograph on Tamoxifen. It is regrettably true that overviews, even when up to date after exhaustive research - the shibboleth of our cultures -, rapidly lose relevance with the passage of time. Scientists can sometimes be pictured as deep sea divers, who plunge into the unknown in search of a hitherto unknown world. Their descent is exciting, but eventually they must come up for air and integrate their experiences with others who also had to resurface. This book intends to collect and, where possible, to collate recent, but sometimes seemingly unrelated information. To quote Stephane Mallarme: "Everything in the world exists to end up in a book". Even if this is a tad cynical, it might not be far from the truth. If a little knowledge is a dangerous commodity, one can also add - tongue in cheek - that a vast amount of knowledge can be truly hazardous. It is likely that what might seem as entangled data is confusing, especially for those satisfied with the comfortable interpretation of Tamoxifen as an antiestrogen which has long been found insufficient. The complexity of its mechanisms and effects defies simple explanations and may even seem capricious, but only because of our ignorance.
 

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Contenido

THE ENIGMA OF TAMOXIFEN
1
2 ASSESSING NEOPLASIA
25
3 INTERACTIONS OF TAMOXIFEN WITH LIPID SIGNAL TRANSDUCTION CASCADES
43
4 CARCINOGENICITY OF TAMOXIFEN
59
5 MECHANISMS OF RESISTANCE TO ANTIESTROGENS AND THEIR IMPLICATIONS FOR CROSSRESISTANCE
93
6 TAMOXIFEN AND MULTIDRUG RESISTANCE IN CANCER
123
7 THE EFFECT OF TAMOXIFEN ON THE IMMUNE RESPONSE
137
8 CELLULAR EFFECTS OF EARLY EXPOSURE TO TAMOXIFEN
179
11 TAMOXIFEN AND THE ECADHERINCATENIN COMPLEX
267
12 REGULATION OF GROWTH FACTOR GENE EXPRESSION BY TAMOXIFEN
285
13 TAMOXIFEN AND DRUGMETABOLIZING ENZYMES
303
14 MEMBRANE ANTIOXIDANTMEDIATED CARDIOPROTECTIVE ANTICARCINOGENIC ACTIONS OF TAMOXIFEN
321
15 ANTIESTROGEN REGULATION OF erbB2 EXPRESSION IN HUMAN BREAST CANCER CELLS
343
16 ENHANCEMENT OF THE ANTINEOPLASTIC EFFECTS OF TAMOXIFEN BY SOMATOSTATIN ANALOGUES
359
17 CONCLUSIONS
369
Index
375

9 THE COVALENT BINDING OF TAMOXIFEN TO PROTEINS AND DNA
201
10 TAMOXIFEN METABOLISM AND OESTROGEN RECEPTOR FUNCTION IMPLICATIONS FOR MECHANISMS OF RESISTANCE IN BRE...
231

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Referencias a este libro

Immune Modulating Agents
Kresina
Vista previa limitada - 1997

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