AIDS PathogenesisH. Schuitemaker, Frank Miedema Springer Science & Business Media, 2000 M03 31 - 282 páginas Infection with the human immunodeficiency virus is characterized by the destruction of the host immune system as also reflected by a progressive loss of CD4-positive T-cells. This finally results in the host's incapacity to deal with opportunistic infections and the immune surveillance of tumors, a clinical status known as the Acquired Immunodeficiency Syndrome (AIDS). The book AIDS Pathogenesis provides the reader with a complete overview of the clinical course of HIV-1 infection. It describes the clinical aspects of primary infection, the different clinical outcomes of HIV-1 infection, and strategies for anti-viral treatment. In addition, more fundamental aspects of HIV-1 infection are reviewed. These include the biology of the virus and the novel insights in AIDS pathogenesis. Not only is the significance of an HIV-specific cellular and humoral immune response discussed, but also the possible incapacity of the adult human host to deal with T-cell destruction. Finally, the book discusses the currently used laboratory markers that allow for monitoring of the clinical course of infection. |
Contenido
I | 1 |
II | 19 |
III | 41 |
IV | 55 |
V | 65 |
VI | 77 |
VII | 99 |
VIII | 133 |
XI | 177 |
XII | 195 |
XIII | 209 |
XIV | 221 |
XV | 243 |
XVI | 261 |
XVII | 273 |
XIX | 279 |
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Acad activity AIDS Res anti-retroviral therapy antibody response antigen antiviral assays associated asymptomatic biological phenotype carinii CCR5 CD4 counts CD4+ cells CD8+ T cells Clin clinical co-receptor cohort correlation cytokines Cytomegalovirus detected didanosine disease progression drug Engl epitopes factors gene genotype glycoprotein HAART herpesvirus HIV replication HIV-1 infection HIV-1 isolates HIV-1-specific CTL responses HIV-RNA homosexual human immunodeficiency virus Human Retrovir immune response immunodeficiency virus infection immunodeficiency virus type Immunol immunological increased individuals inhibitors Kaposi's sarcoma Kaposi's sarcoma-associated herpesvirus KSHV Lancet levels long-term LTNPs lymphoma macaques macrophages markers Miedema monoclonal antibodies Moore mutations Natl neutralising antibody neutralization opportunistic infections pathogenesis patients peripheral blood phenotype plasma primary HIV infection primary isolates progression to AIDS protease protein Sattentau Schuitemaker seroconversion serum Sodroski studies suppression T-cell transmission treatment V3 loop vaccine variants viral load viral replication virions Virol virologic virus type-1 viruses vitro vivo zidovudine