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with imported ones, which are free. This is urged as a reason why the tax should be abolished! If we manacle our own productions and leave foreign competition unfettered, surely this, instead of violating the principle of free trade in our own interests, would be running it to seed in an opposite direction !

If this be a question of general public interest, then surely the general public are entitled to have facts placed before them in a straightforward simple manner. On the 17th of May last a circular was issued from Somerset House, signed W. H. Cousins, and addressed to the principal wholesale medicine vendors-i.e., to those wholesale firms whose business it is to stock patent proprietary medicines of all descriptions for supply to the ordinary channels of trade (principally to retail druggists), of which the following is a copy :

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Inland Revenue, Somerset House, W.C., 17th May, 1884. Gentlemen, The Board of Inland Revenue have reason to believe that some misapprehension is prevalent with regard to the liability to Stamp Duty of Foreign Medicines imported into this country and subsequently exported for sale abroad.

In these circumstances they have directed me to point out to you and to the other principal dealers in Patent Medicines and Proprietary Articles that all Foreign Medicines (except pure drugs) are liable to Stamp Duty; and that if exported by English houses to meet orders received from abroad, or from Ireland, the Isle of Man, or the Channel Islands, they must be stamped.

Where, however, an English house merely acts as Agent for the Foreign Manufacturer, and passes on Medicines in bulk to other Agents residing out of Great Britain, without any actual sale taking place, a Stamp is not required.

W. H. COUSINS.

I enclose for your information Extracts from the Acts of Parliament imposing and regulating the Medicine Duty. I am, Gentlemen, your obedient Servant, Let it be particularly noted that this circular was issued to the wholesale trade, and not to the manufacturers of patent medicines, and that, referring as it does to "foreign medicines," the home manufacturer is not placed in the disadvantageous situation mentioned by "NonPractitioner."

America sends us a great many medical specialities which have hitherto i.e., prior to May 17th-found their way into the English market free of duty, notwithstanding that English pharmaceutical preparations entering her ports are heavily mulcted. It is these American preparations which will in future be chiefly affected, so that, after all, the advocacy for repeal is more in the interests of the American speciality

manufacturer than the English one.

Coming now to the second letter, I would say that it is by no means clear that Charlatanry would cease with the abolition of the stamp. It may be quite true; and no doubt is so, that facts are often so arranged by some makers of nostrums as to convey on the face of them a totally erroneous impression. But would the extinction of the stamp be a death blow to the ingenuity of the quack? Let the "Member of the Royal College of Physicians" pay a visit any Friday to the Metropolitan cattle market, and he will probably be convinced that the public can be persuaded to try medical experiments without that great power of evil, the patent medicine stamp. This place is merely one among thousands where quackery requires no "Government endorsement." As to the question" Should a Government lend itself to puffing the deleterious stuff which charlatans palm oft upon a credulous public?' I reply certainly not; and I, for one, would not so grossly insult Government as to insinuate that they ever did any such thing. Licences are granted to drivers of hackney and stage carriages, and these drivers wear each his distinguishing number, but that is no guarantee of safety to the passenger-no assurance that the cabman will not attempt to overcharge, or that he will treat his fare with strict courtesy at pay-time. If the public be credulous, can legislative wisdom change that condition? Possibly; but only by an educational process, and not by enactments aiming at making gullibility impossible.

But is "Member of the Royal College of Physicians" incorrectly informed? or is he himself practising that which he condemns in the charlatan? I will be charitable enough to suppose the former, and for his benefit state very plainly and clearly, that the stamp does not touch the alkaloids. Quinine, for instance, is NOT HELD LIABLE TO STAMP

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To the Editor of the "Midland Medical Miscellany." SIR,-There are a few facts in connection with patent medicines that appear to have been overlooked by those who have recently clamoured so loudly for the immediate repeal of the Patent Medicine Stamp Act. First, the present Pharmacopoeia contains a number of preparations remedies; thus, black drop, Ward's paste, Daffy's elixir, Huxham's which are simply imitations of well known patent medicines, or secret tincture of bark, De Valengin's solution, Fowler's solution, Turlington's drops, Dover's powder, Singleton's ointment, and many others, have Of the more recent secret official imitations in the Pharmacopoeia. Preparations which have been thus imitated may be mentioned Bishop's citrate of magnesia, Schacht's liquor bismuthi, Condy's fluid, etc. These official imitations are by no means always preferred by medical men to the original preparations, which are not unfrequently specially ordered by name on physician's prescriptions. It is obvious therefore, that if, as stated in the Lancet, "scarcely a day passes without the record in the papers of an inquest on some poor deluded victim who has been sent to his last account from an overweening confidence in one or other of the have been sent on the same road by an overweening confidence in much belauded patent medicines," it is impossible to say how many may physician's prescriptions, which contain imitations of these same preparations. Second, the records of the past few years give the direct lie to the above statement quoted from the Lancet. On turning during the year 1883, it will be seen that there were 8 deaths from to the Registrar General's report on deaths from poisoning, patent medicines, and 8 from chlorodyne, against 20 from chloral hydrate, 129 from opium and its preparations, 20 from alcohol, 50 from carbolic acid, 16 from oxalic acid, 121 from strychnia and nux vomica, 24 from prussic acid and oil of almonds, 22 from potassium cyanide. It will be observed from the above abstract, that the public safety is less endangered by the use of patent medicines than by substances used in prescriptions, such as opium, chloral hydrate, strychnia, prussic acid, and In the report for the year 1884, the deaths are given as 4 from patent medicines, and 6 from chlorodyne, while the deaths from chloroform are 5, ether 1, chloral 15, opium and its preparations 116, alcohol 26, oxalic acid 26, carbolic acid 34, strychnia and nux vomica 23, prussic acid and oil of almonds 15, and potassium cyanide 16; there are also 8 deaths from poisonous fish and meat. It is thus evident that the danger to the public from taking 19,000,000 packets yearly of patent medicines is an extremely small percentage, considerably less indeed, in all probability, than from pharmacopoeial medicines used in

carbolic acid.

prescriptions.

Third, certain patent medicines have died out. This result is bound to follow if the medicines themselves are worthless, or do not effect what the advertisement professes. The obvious conclusion remedies, while a few, such as chlorodyne, which are preferred by the therefore is, that many patent medicines are fairly good domestic medical profession to the official preparations, cannot be refused to the public on the ground of danger any more than the repetition of a physician's prescription without his authority. Patent medicines are usually taken for one of the following reasons:-First, because the patient hopes to avoid a doctor's bill by the use of a well-known medicine, from which others have found benefit; second, because they see them advertised; and lastly, on the recommendation of a friend, The who has already been relieved of pain or disease by their use. first time a patent medicine is taken it may be regarded as an experi ment, in which the patient takes the risk; but the second time the patient takes it, it is because beneficial results have been found in his or her case to follow its use. Patent medicines thus proved, not unfrequently become established as domestic remedies. With regard to the future of patent medicines, it seems to have escaped observation by those who are so anxious for the repeal of the patent Medicine Stamp Act, that the removal of the tax (for it is nothing more) would be the taking of £160,000 yearly out of the national income, which would have to be added to the income tax, or obtained by some more objectionable tax, while it would naturally increase the sale of patent medicines by allowing the proprietor the value of the stamp to spend

in additional advertisements.

London, October 21st, 1884.

VERITAS.

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The

Midland Medical Miscellany,

VOL. III.

AND

Provincial Medical Journal.

Ellustration.

THOMAS M. DOLAN, M.D.

DECEMBER 1, 1884.

FOR our memoir this month we have selected a typical example of the general medical practitioner and poor-law medical officer. Thomas M. Dolan, M.D. Durh., F.R.C.S. Edin., and L.S.A. Lond., was born at Cashel, county Tipperary, a place celebrated for the interesting ruins of Hare Abbey or Grey Friars, the Dominican Abbey, and those on the celebrated Rock of Cashel. This city was formerly the metropolis of the Kings of Munster, and in the cathedral was deposited the Lia Fail, or fatal stone, on which they were crowned. In 513 Fergus, a prince of the Royal line, having obtained the Scottish throne, procured the use of this stone for his coronation at Dunstaffnage, where it continued until the time of Kenneth II., who removed it to Scone, from whence it was removed to England by Edward I. in 1296. It is now under the coronation chair at Westminster. He received a liberal education at Ushaw College, Durham, a college specially distinguished for its course of Litera Humaniores, and subsequently studied at Steevens's Hospital, Dublin, and after obtaining three diplomas in August of 1866, commenced practice in Halifax in November of the same year.

In 1869 Dr. Dolan was appointed medical officer to the Halifax Union Infirmaries, which position he has retained up to the present time. At the time of his appointment the wards placed under his charge were of the old workhouse character, but upon the attention of the Halifax guardians being drawn to their shortcomings, they at once proceeded to erect infirmaries, which may fairly vie with any similar institution as regards structure and general requirements. Workhouse infirmaries, although not at present fully recognised as fields of observation, supply abundant means of pursuing practical medicine in its various branches; and the work done by such men as Hutchinson, of spirometer fame,

No. 36.

North, of York, Stretch Dowse, of London, and Alexander, of Liverpool, furnishes abundant evidence of their value as a field of medical research.

In the Halifax district hydrophobia being of comparatively frequent occurrence, Dr. Dolan's attention was thus directed to this disease. This resulted in the production of his work on "Hydrophobia," published in 1878. The favourable review of this work by Sir Joseph Fayrer, in "Brain," at once attracted attention. once attracted attention. The first edition was published without a name; the second edition appeared with the author's name; and of it Sir Joseph Fayrer writes: "It is by far the most complete work on the subject I have seen, and I am very glad to find it has been, as it deserved to be, so successful." In the hydrophobia competition, offered by F. V. Bennett Stanford, in 1879, Dr. Dolan sent in a contribution which was regarded of such merit that it obtained a recommendation from the adjudicators-Drs. Brunton, Dickinson, and Ferrier-that the sum of £50 should be specially raised and awarded to him. This competition was open to all nationalities; there were nineteen competitors, and the first prize was awarded to M. Bourrell, a veterinary surgeon, of Paris.

Dr. Dolan's contributions to medical literature have been numerous. It is only by a systematic method, study, and application, that a general practitioner could have accomplished so much work; but the writings of Dr. Dolan prove how much can be done even by a practitioner holding important public appointments, and, besides, enjoying a large clientèle. He has by his pen advocated the cause of the poor-law medical officer. In 1875 he published in the Medical Press and Circular a series of articles on Life Assurance for Poor-Law Medical Officers; and in 1881 he obtained the prize of £100 for the best essay on Life Assurance-a competition instituted by the Equitable Life Assurance Company of the United States, in which there were one hundred and sixty-three competitors. The judges for this competition were S. E. Hall, Esq., and Cornelius

RENDER FOOD POISONOUS.

ADDRESS DELIVERED ΤΟ THE SANITARY CONGRESS, DUBLIN, OCT. 3RD.

BY CHARLES A. CAMERON, M.D., S.S. C. (Camb. Univ.),
Vice-President and Professor of Hygiene and Chemistry R.C.S.I.; Vice-President,
Institute of Chemistry of Great Britain; Medical Officer of Health, Dublin.
II.

SPIRO BACTERIA.

of the most interesting of the disease producing spirilla is
I shall now briefly notice the vibriones and spirilla. One
that causing relapsing fever in man. It is called after its
discover, Spirillum Obermeyeri. These organisms are
blood during the paroxysms of the fever, and almost com-
minute wavy threads, which appear in great numbers in the
pletely disappear when the fever subsides for the time.
Relapsing fever is also termed "hunger" fever, as it often
found in putrefying substances, and no doubt exercise
Several kinds of spirilla are
prevails during famines.
a septic action.
a septic action. The vibriones are also septic; they are
curved rods, which exhibit rapid movements. The coloured
substances formed in paste, water, etc., are often caused
by spirilla. One species is found in the tartar of teeth.

Walford, Esq., with Tom Hughes, Q.C., as referee. In ON MICRO-ORGANISMS AND ALKALOIDS WHICH November, 1878, he contributed to the Obstetrical Journal some facts on "Puerperal Septicæmia," and in the following AN year "An Analysis of 1785 Consecutive Labours." A series of articles on "The Effects of Drugs during Lactation on either Nurse or Nursling" were contributed to the Practitioner in 1879. On these papers the editor of that journal (Dr. Landor Brunton) wrote:- "These admirable papers were sent to America in competition for the Boylston Prize. This valuable prize would have been awarded to them; but, most unfortunately, the publication of a part of them in the Practitioner previous to the award deprived the author of the prize." Not discouraged, however, by this, he in the following year again contributed, and obtained the Boylston Prize of three hundred dollars for his essay on "Sewer Gas: its Physiological and Pathological Effects on Animals and Plants-an Experimental Inquiry." Among the pamphlets published by Dr. Dolan may be mentioned "Drink and Pauperism," "Remarks on Workhouse Hospitals, with illustrative cases," and also a paper on "The Relation of Workhouse Infirmaries to our Hospital System," in the report on Hospital Management, issued by the Social Science Association in 1882. In that year he obtained the Fothergillian Gold Medal of the Medical Society of London for his essay on "Whooping Cough its Pathology and Treatment," and in 1883 gained the prize given by the Medical Institute of Valencia, in Spain, for his essay on "Heart Disease." During the present year Dr. Dolan has frequently contributed to our columns, among them being a series of papers on "The Poor-Law Medical Service: its Past, Present, and Future," in the course of which he reviews the Poor-Law Medical Service from the time of the passing of the PoorLaw Amendment Act of 1834-35 to the present time. There is no doubt the Poor-Law Medical Service is open to great improvement, and the suggestions by Dr. Dolan, if adopted, would do much to improve the prospects of professional men in the service of the State. The paper upon "Dangers to Health in Houses, Foods, and Drinks," which we gave in our October issue, was delivered as a lecture at the Dean Clough Institute, Halifax, and from the sanitarian point of

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METAMORPHOSIS OF MICRO-ORGANISMS. Experiments have been made for the purpose of ascertaining-first, whether or not the artificial cultivation of harmless bacteria and micrococci might be conducted as to render them pathogenic or disease-giving; and, second, whether or not the cultivation of pathogenic organisms might not be so managed as to moderate or destroy their virulence. As to the first of these attempts Hans Buchner asserts that he converted the harmless hay bacillus into the deadly anthrax bacillus. According to this author it is not so much the original nature of the micro-organisms as that of the medium in which they are developed, which determines their pathogenic power. He cultivated the hay bacillus in defibrinated blood, maintained at a temperature of 36° Cent., and found that after a few generations the descendants of the innocuous bacteria acquired virulent properties. When introduced in small numbers into the blood of a healthy animal they appeared to cause its death, and the post-mortem appearances were similar to those of poisoning by anthrax bacilli.

of the hay bacillus. He points out that the material first Koch asserts that Buchner has not changed the nature used by Buchner for his cultivation was egg albumin which had not been sterilised, and which, therefore, might have contained the bacilli which give rise to malignant cedema. These micro-organisms are not uncommon in putrefying organic substances. They develop rapidly in the blood, in which liquid the hay bacillus languishes. Koch, and also Klein, therefore, are of opinion that Buchner introduced into the blood both kinds of bacilli, and that the hay bacilli soon died out, whilst the other kind multiplied under conditions so favourable to their growth.

With respect to the conversion of baneful into innocuous or comparatively innocuous micro-organisms, Pasteur claims to have accomplished that triumph, so also do Buchner, Toussaint, Koch, and others.

ably contains great numbers of bacilli. As this fever is The blood of animals affected with splenic fever invari

* Ueber die experimentelle Erzegung des Milzbrandcontagiums aus den Heupilzen.

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