ImmunotoxinsArthur E. Frankel Springer Science & Business Media, 1988 M05 31 - 566 páginas Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good indepth reviews of cancer topics, and published symposium lectures are often the best overviews available. Un fortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up-to-date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more. |
Contenido
Introduction | 1 |
Toxin Structure | 9 |
Toxin structure | 11 |
Structureactivity relationships in diphtheria toxin and Pseudomonas aeruginosa exotoxin A | 25 |
How Toxins Work | 37 |
How protein toxins enter and kill cells | 39 |
Mechanism of action of ricin and related toxins on the inactivation of eukaryotic ribosomes | 75 |
Toxin Selection and Modification | 91 |
Growth factors and other ligands | 297 |
Purification and Chemical Characterization | 321 |
Purification and biochemical characterization of immunotoxins | 323 |
Enhancers | 349 |
19 Immunotoxin enhancers | 351 |
Enhancement of immunotoxin action Manipulation of the cellular routing of proteins | 371 |
Cytotoxicity | 391 |
Methods for quantifying immunotoxin efficacy | 393 |
Toxin selection and modification Overview | 93 |
Toxin selection and modification Utilization of the A chain of ricin | 97 |
Genetic engineering of immunotoxins | 113 |
Diphtheriarelated peptide hormone gene fusions A molecular genetic approach to chimeric toxin development | 123 |
Immunotoxins containing ricin | 141 |
Pseudomonas exotoxin Immunotoxins | 161 |
Immunotoxins containing single chain ribosomeinactivating proteins | 175 |
Covalent Linking Agents | 211 |
Antibodytoxin conjugation | 213 |
Effect of chemical linkage upon the stability and cytotoxic activity of A chain immunotoxins | 239 |
Antibody Selection | 253 |
Immunotoxins Selection of cellsurface antigens and their corresponding monoclonal antibodies | 255 |
Nonantibody Ligands | 279 |
Hormone lectin and toxintoxin conjugates | 281 |
Kinetic analysis of cytotoxicity | 405 |
Isolation and analysis of somatic cell mutants resistant to toxin conjugates | 417 |
Animal Studies | 431 |
Immunotoxin therapy Assessment by animal models | 433 |
Prevention of carbohydratemediated clearance of ricincontaining immunotoxins by the liver | 457 |
Human immune response to immunotoxins | 475 |
Clinical Studies | 481 |
Treatment of leukemia patients with T101 ricin A chain immunotoxins | 483 |
Clinical studies Solid tumors | 493 |
Immunotoxins for ex vivo bone marrow purging in human bone marrow transplantation | 515 |
Conclusion | 537 |
549 | |
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Términos y frases comunes
A-chain abrin Acad activity affinity anti-Thy antibody-ricin antigen antitumor assay binding Biochem Biol Biophys bone marrow Cancer Res carbohydrate cell lines cell surface chain conjugate Chem chemical chloroquine chromatography clearance clinical concentration conjugate containing crosslinking cytosol cytotoxicity diphtheria toxin disulfide bond domain dose effect efficacy endocytosis endosomes enzyme exotoxin Figure galactose gelonin gene glycoprotein groups human hybrid immune Immunol immunotoxins inactivation inhibition injected insulin intact ricin intracellular ionophores killing kilodalton kinetics lactose lectins leukemia cells ligand linkage linked liver mannose melanoma membrane mice modeccin modified moiety molecules monensin monoclonal antibody mouse murine mutants Natl NH4Cl Olsnes patients potential protein synthesis Pseudomonas exotoxin purified reagents residues ribosome-inactivating proteins ribosomes ricin A chain rRNA single chain SPDP specific structure studies subunit target cells Tf-A therapy thiol tion tissues toxicity toxin entry translocation treatment tumor tumor cells uptake Vero cells vitro vivo Youle
Pasajes populares
Página 429 - WS, 1983, Defective acidification of endosomes in Chinese hamster ovary cell mutants "cross-resistant" to toxins and viruses, Proc. Natl. Acad. Sci. USA 80:5315-5319.
Página 33 - O., and Kato, I. (1968) Diphtheria toxin-dependent adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis. J. Biol. Chem. 243, 3553-3555.
Página 33 - Y. (1978) One molecule of diphtheria toxin fragment A introduced into a cell can kill the cell. Cell 15, 245-250.
Página 121 - Evidence for receptor-mediated binding of glycoproteins, glycoconjugates, and lysosomal glycosidases by alveolar macrophages, Proc.