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deceptions than that they afford exceptions to a law of the human animal economy?"

These confiderations, properly attended to, it is hoped will have that due weight in every candid mind to which they are fo justly entitled; and if they have that effect, which the editor conceives they muft, they will inevitably destroy any kind of doubt which a perufal of Mr. Goldfon's pamphlet might produce. Much more might be faid refpecting the experiments made on this fubject by other gentlemen in Europe, as well as by the phyficians of this city, and by others on the continent of America;-but as it is prefumed thofe above mentioned are amply fufficient, fo it is unneceffary to occupy our readers with any more; for, if after perusing the above, any should be so sceptical as to doubt, we may fay with fcripture, "neither would they believe though one should rife from the dead."

As it may have fome weight in the fcale of truth to fhew, that we have not hesitated to make the experiments on our own children, which we have inftituted upon others, and as we have perhaps tried it more frequently in one cafe, than we know to have been done before, it is prefumed the following statement will not be unacceptable.

On the 29th of December, 1801, a few weeks after the introduction of the vaccine into Philadelphia, I vaccinated my fon Edward Jenner Coxe, aged three weeks, with infection of the ninth day, then fourteen days oldt. The difeafe fucceeded to

* We do not pretend that we are able to prove in what respects the cafes were deceptions; on the contrary, in place of rejecting, we must admit them according to the statements; and future obfervations can alone explain fuch anomalies.

†The infection employed was taken from a perfon, who had it excited in her, by virus from the arm of a gentleman to whom I had communicated it from myfelf. It was confequently the third remove from me. Dr. Pearfon having denied the poffibility of exciting the vaccine after the fmall pox, I have only to ftate the above to prove the fact.—Editor.

my utmost wishes, no indifpofition was perceptible throughout. I tefted him with fmall pock matter on the 20th of January, 1802, and again on the 29th of the fame month; on the 18th of February, I repeated it; but all failed. I therefore omitted any further attempt till the 23d of February of the following year, 1803. This failing, I repeated it on the 29th of April, with a fimilar refult. In the prefent year, 1804, I renewed my attempts, on the 31st. of January, the 29th. of May, and lately on the 20th. of October. These have all uniformly failed, though generally made with fresh infection, taken from perfons labouring under the confluent fmall pox.-In two or three of the attempts, a fmall puftule appeared, rapidly declining, except once, when from rubbing, it produced a flight ragged fcab-which would probably have been the case with any common fore, from a fimilar accident. I have, befides the above. attempts to excite the disease by the infertion of matter, given him the chance of taking it, by above a dozen exposures to the natural small pox. He has been held in the arms of perfons labouring under it, and has been for a week together, expofed a confiderable time daily to patients, brought to me, covered with puftules. This I conceive to be conclusive evidence, not to be overthrown, by cafes, problematical at least,-or depending on circumstances not at prefent perhaps fufficiently understood in the hiftory of the difeafe.*

EDITOR.

⚫ It is a very aftonishing circumstance, that so much clamour fhould be raifed against vaccination, and fuch doubts excited against its efficacy, from the rumours of a few unsuccessful cafes, which, if properly investigated, before circumstances effential to their history are forgotten, would be found to originate in error; whilft it is not adverted to, that if the vaccine was not an abfolute preventive of the fmall pox; instead of a few (at beft) doubtful cafes of fupervening small pox, hundreds, nay, thousands of cafes, not admitting of the smallest doubt, would, ere this, have come before the public. This is perhaps as ftrong a ground to rest upon, as could be taken. Amidst all this uneasiness alfo, we fee the small pox continually exerting its baleful influence on hundreds of our unfortunate fellow-mortals, who are expofed to it. In New-York, where regular weekly returns of deaths are made, by an inspector appointed for the purpose, we find, that fince the beginning of November to the 8th of Decem

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Extract of an original Letter from Thomas Hackett to J. & H. Phillips, dated Duck-creek, April 10, 1720.

"Since you went hence I wrote you four times, though I have yet heard nothing of you, and impatiently expect a letter from you. I hope you got well home, and it has been of late a great fatisfaction to me that you went when you did, for this winter and spring we have been vifited in these parts with fuch a mortality as exceeds the laft great plague in London, quantity for quantity of people confidered, (as thofe that remember that fay,) in fhort, it has in a manner laid this place defolate. I cannot recount to you the names and number of the dead; but to give you fome notion of the terrible havock, I will name a few particulars. Jofeph England loft his wife and thirteen or fourteen children and fervants; out of Worral's family, fix people; John Smith, wife, and boy; two children of Empfon's dead, and his wife hardly recovered it; Matthew Corbit and his wife; William Cummins and wife; Isaac Corbit, John Cook, Abfalom Cuff and fon, all dead; and last week your cousin Sall Mifflin; but thefe are but a few, for you to guefs at the terror of the vifitation by. I thank God, brother's family has escaped yet; and at the manor, Robert Vessy only is dead, though West and Abigail were both fick at the fame time alfo. I have been hitherto well in health, but it ftrangely furprifed me; and I fear and expect my fate will be to lay my bones here, though hope, the last thing that leaves man in this world, ftill relieves me with the thoughts of feeing you next year, as by God's help I intend to do."

ber, upwards of 70 perfons have fallen victims to its fury. (If the fame mortality exists throughout the year, not less than 500 perfons must be annually carried off by it.) If the fame regular returns were made in Philadelphia, there is reason to believe at least 100 persons would be found to have funk under this direful scourge during the fame period. Let those who advocate the mall pox-in opposition to vaccination-think seriously of this!-Editor..

As the preservation of even imperfect details of the diseases of our country, is of importance, I have extracted the above from the original letter in my poffeffion. Although it gives us no idea of the nature of the difeafe adverted to, perhaps there may yet remain fome documents on the fubject, which may be brought to light by it, and which would be highly acceptable to the editor. It may not be improper to remark, that this was the year, in which the plague raged with fuch unprecedented violence in Marseilles.

EDITOR.

Extract of an original Letter from William Monington to Andrew Ruffel, dated Philadelphia, 26th 7th mo. 1700.

"OUR arrival here was in the beginning of corn harvest; the weather grew very hot and fainty, and fome of our passengers that went presently to harvest work, fpent themselves in the heat, and expired in the fields.

"The heat continued and a fickly time came on; the diftemper was generally accounted peftilentious; it feized with a vi olent pain in the head and back, and caufed vomiting blood. Few over-lived feven days after they were taken ill, and very few recovered. From the beginning of the 6th month till the latter end of the 8th month, there died of friends and others, (befides thofe that were burled in the church-yard) to the number of 170 men, women and children; but afterwards the violence of the distemper abated, and very few died.

"The fame distemper, it is faid, was very mortal in Barbadoes, and alfo upon the feas. In the time of the fickness here, arrived the Britannia from Liverpool, that brought two hundred paffengers and thirty feamen from England; of whom about fifty-eight died on the feas, (as they faid of the fame distemper*); Thomas Mufgrave was one, and feveral others of them died here."

*This disease on board the Britannia, was, more probably, the jail or hofpital fever, produced from the crowded and unventilated fate of the fhip.-- Bditon.

THE bilious remitting and intermitting fever has prevailed during the last fummer and autumn, very generally in the high grounds in Pennsylvania. Dr. M'Cleland gives the following account of it as it appeared in Franklin county, in a letter to Dr. Rush, dated November 17, 1804.

It appeared, the doctor writes, in all the forms of a malignant, common bilious, and intermitting fever. It was fo general, that scarcely a family, and in fome families fcarcely an individual escaped it. The remedies for it were bleeding, purging, sweating, a falivation, and the bark, according to the force, type, and stages of the disease. Few died where medical aid was called foon, and the above remedies used. It was most fatal to the Germans who either neglected to fend for physicians, or relied upon quacks. Relapfes were very common. They occurred in no cafe where a falivation became necessary to cure the fever. The extent of the difeafe may readily be conceived, when it is added, that the doctor administered to his patients ONE HUNDRED AND THIRTY POUNDS of bark in the course of the seafon, and would have administered more, could he have procured it. He afcribes this epidemic to the warm weather which fucceeded the frequent rains in his neighbourhood during the fummer, and to the exhalations which were the refults of them.

The "Shamaul" the hot wind of the defert, is stated by the author of a late voyage to Malta, from the information of a Moor (his friend) to have carried off in the defart, of a caravan of 70,000 pilgrims, one-feventh of the whole, or 10,000 perfons, and of his own particular party of 13, nine died.

From the Georgia Republican.

Meffrs. LYON & MORSE,

The following cafe proves that an excess of alkali, fometimes exists in the human stomach.

Being feized one morning with the fickness of stomach termcd pyrofis fputatoria, called water-brab in Scotland and Ireland,

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