Growth HormoneKemal Bengi Springer Science & Business Media, 1999 M05 31 - 359 páginas Growth Hormone is a fitting addition to the Endocrine Updates Series. The aim of these publications is to provide the clinician with cutting-edge, yet succinct, access to the latest advances in endocrinology. Current interest in this rapidly evolving area of endocrinology makes this a timely and important update. Growth Hormone joins Dr. Fagin's Thyroid Cancer in continuing the standard of excellence as the fourth volume in this series of topical updates. Shlomo Melmed, MD, Series Editor, Endocrine Updates Ten years ago, many endocrinologists were still skeptical that growth hormone (GH) played an active role in adult metabolism. This is, perhaps, surprising given that GH deficiency (GHD) in adulthood had been `recognized' as long ago as the 1960s. During the last ten years studies have shown that GHD in adulthood is a far-reaching syndrome associated with abnormal body composition, reduced bone mineral density with an increased fracture rate, increased cardiovascular morbidity and impaired cardiac function, as well as reduced exercise performance and decreased psychological well-being. Importantly, it is also clear, from placebo-controlled trials, that GH replacement therapy can normalize body composition, increase bone mineral content and improve the cardiovascular risk factor profile. GH replacement therapy also improves cardiac performance and exercise capacity, increases muscle strength and improves well-being and quality of life. The aim of Growth Hormone is to provide a critical update of current knowledge about adult GHD and the future role of GH/IGF-1 in adult medicine. For this purpose, contributions from a number of research groups have been invited. It is my hope that the book may not only serve as an introduction to the field, but also stimulate further research within this exciting area. |
Contenido
Neuroendocrine control of growth hormone secretion | 3 |
Signal transduction through the growth hormone receptor | 17 |
Growth hormone binding proteins | 37 |
Regulation of insulinlike growth factorI and its role in controlling growth and metabolism | 59 |
The insulinlike growth factor IGF binding proteins GFBPs | 77 |
The etiology of growth hormone deficiency in the human adult | 97 |
The diagnosis of growth hormone deficiency | 109 |
Adult growth hormone deficieny the clinical picture | 127 |
Effects of growth hormone on blood coagulation and fibrinolysis | 173 |
Growth hormone and the immune system | 189 |
Effects of growth hormone on muscle mass and function | 227 |
Effects of GH on bone metabolism and bone mass | 237 |
GH effects on cardiac function | 253 |
Psychological wellbeing in growth hormone | 261 |
Dose titration and monitoring GH treatment in the adult | 281 |
Side effects of growth hormone treatment | 291 |
Growth hormone replacement therapy in adult GH deficient patients | 133 |
Effects of GH on body composition | 135 |
Effects of GH on lipid metabolism | 149 |
Effects of growth hormone on glucose and protein metabolism | 163 |
New frontiers in adult GH therapy | 307 |
Growth hormone in heart failure | 309 |
GH and catabolic state | 325 |
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Términos y frases comunes
acromegaly action activity adults with growth amino acid Bengtsson B-Å Biol body composition bone mass brain cardiac cardiovascular cells Clin Endocrinol Metab Clin Invest clinical concentrations decreased demonstrated diabetes disease dose effects of GH effects of growth Endocrinology extracellular factor-I fibrinogen function GH and IGF-I GH deficiency GH receptor GH release GH replacement GH response GH secretion GH stimulated GH therapy GH treatment GH-deficient adults GHBP levels GHRH GHRP glucose growth factor binding growth hormone deficiency growth hormone GH growth hormone receptor growth hormone treatment growth hormone-binding protein heart failure hormone deficient adults human growth hormone hypopituitarism hypothalamic IGF-I IGFBP-3 IGFBPS increased inhibition insulin insulin-like growth factor Isgaard JAK2 Johannsson kinase lipid lipoprotein Lp(a lymphocytes mediated mice mRNA muscle neurons normal osteoblasts peptide pituitary placebo plasma protease protein synthesis recombinant human growth reduced regulation replacement therapy role Rosén serum somatostatin studies syndrome tissue vitro vivo
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Página 302 - Salomon F, Cuneo RC, Hesp R, Sonksen PH. The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency.