Tamoxifen: Beyond the Antiestrogen

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Springer Science & Business Media, 2012 M12 6 - 378 páginas
Tamoxifen has persisted as a widely accepted and administered drug for almost 25 years. Following the many scientific papers and books on the subject, it has remained a very intriguing substance. This, perhaps, is the reason for another monograph on Tamoxifen. It is regrettably true that overviews, even when up to date after exhaustive research - the shibboleth of our cultures -, rapidly lose relevance with the passage of time. Scientists can sometimes be pictured as deep sea divers, who plunge into the unknown in search of a hitherto unknown world. Their descent is exciting, but eventually they must come up for air and integrate their experiences with others who also had to resurface. This book intends to collect and, where possible, to collate recent, but sometimes seemingly unrelated information. To quote Stephane Mallarme: "Everything in the world exists to end up in a book". Even if this is a tad cynical, it might not be far from the truth. If a little knowledge is a dangerous commodity, one can also add - tongue in cheek - that a vast amount of knowledge can be truly hazardous. It is likely that what might seem as entangled data is confusing, especially for those satisfied with the comfortable interpretation of Tamoxifen as an antiestrogen which has long been found insufficient. The complexity of its mechanisms and effects defies simple explanations and may even seem capricious, but only because of our ignorance.
 

Contenido

Assessing Neoplasia
25
Interactions of Tamoxifen with lipid signal transduction cascades
42
Carcinogenicity of Tamoxifen
68
Mechanisms of resistance to antiestrogens and their implications
93
Tamoxifen and multidrug resistance in cancer
123
The effect of Tamoxifen on the immune response
137
Cellular effects of early exposure to Tamoxifen
179
The covalent binding of Tamoxifen to proteins and
201
Tamoxifen metabolism and receptor function implications for
231
Tamoxifen and Ecadherincatenin complex
267
Regulation of growth factor gene expression by Tamoxifen
285
Tamoxifen and drugmetabolising enzymes
302
Antiestrogen regulation of erbB2 expression in human breast
343
Enhancement of the antineoplastic effects of Tamoxifen
359
Index
375
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