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HIV-1 protease inhibitor Nelfinavir reduces rat insulinoma INS-1 cells release insulin
Human immunodeficiency virus 1 (HIV 1) protease inhibitors for the treatment of HIV infection a new class of
antiretroviral drugs, can significantly reduce the mortality of HIV-infected patients, but in these patients the incidence of impaired glucose tolerance and diabetes rate increased significantly, the exact mechanism is unclear, there are experiments show that protease inhibitors can lead to peripheral insulin resistance [1], but its effect on islet β-cell function is not clear whether it will affect. In this study, rats were derived insulin-secreting cell line INS 1 cells as a model, was observed in vitro HIV 1 protease inhibitor <a href="http://www.medchemexpress.com/product/Nelfinavir.html">Nelfinavir</a> on pancreatic β cell function
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